SCIENCE-JOBS-DE

Role of RNA-binding proteins in Leukemia

The recently established research group "RNA Biology and Pathogenesis" (Head: Jun.-Prof. Dr. Tony Gutschner) at the Martin-Luther-University Halle-Wittenberg, Germany, is seeking an exceptionally talented and highly motivated PhD student with an interest and experience in the area of bioinformatics, molecular biology or cancer research, ideally in RNA biology or functional genomics.
The Graduate Student position (13 TV-L, 65%) is available immediately and limited to three years.

The successful candidate will investigate the function of RNA-binding proteins (RBPs) in human leukemia cells and characterize associated phenotypic dependencies. Specifically, the PhD candidate will (I) establish cellular models of cancer-associated RBPs by genome engineering using CRISPR/Cas9 technology and/or lentiviral gene and shRNA transfer; (II) extensively characterize these engineered cell lines phenotypically through, for example, assays for proliferation, apoptosis, and tumor growth in mice; (III) profile these cell lines functionally using CRISPR/Cas9 libraries to identify dependencies; and (IV) mechanistically characterize the most interesting RBPs and functional dependencies in detail in vitro and in vivo using biochemical, molecular and cell biology methods (e.g. Cloning, qRT-PCR, RNA-IP, CLIP; Immunofluorescence).
This position provides an opportunity for the candidate to be creative and innovative, and to work on a challenging, multidisciplinary topic. We offer a close supervision and mentoring. The candidate will have the opportunity to present his/her results at conferences.

Applicants must hold a Diploma or Master’s degree in the fields of bioinformatics or life sciences (biology, biochemistry, molecular medicine, or related disciplines). The successful candidate is a highly motivated, creative, ambitious, and hard-working individual with excellent grades who is passionate about making a difference through cancer research. Strong communication skills, a reliable and accurate scientific working ethic, and the ability to work efficiently, independent as well as in a team, are required. An excellent written and oral command of English is essential. The ideal candidate has a solid background in the field of cancer biology and expertise in molecular and cellular biology, with specific focus on the techniques described above. Knowledge in statistics and bioinformatics would be advantageous.

Applications should consist of (I) a motivation letter mentioning the expected availability date, (II) a recent curriculum vitae incl. an overview of techniques and methods used in the past, (III) a list of publications, (IV) academic degrees and certificates, and (V) contact information of two individuals who could provide an evaluation of the candidate upon request.
Please submit your full application (in electronic form as a single pdf) with registration number 7-176/17-H in the subject line until December 15, 2017 to Jun.-Prof. Dr. Tony Gutschner, E-mail: tony.gutschner@uk-halle.de

More information can be found on our website: http://www.medizin.uni-halle.de/gutschnerlab

The Martin-Luther-University Halle-Wittenberg is an equal opportunity employer. Disabled candidates with equal qualifications will be given preference. Women are strongly encouraged to submit an application.
The announcement takes place pending on fund availability and any possible budget restriction. Application expenses cannot be reimbursed by the Martin-Luther-University.

Anfangsdatum: 15. Februar 2018

geschätzte Dauer: 3 Jahre

Bezahlung: 13 TV-L (65%)

Homepage: http://www.medizin.uni-halle.de/gutschnerlab