Clin Lab. 2014;60(10):1747-55.

The multi-lineage differentiation and angiogenesis ability of adipose-derived adult mesenchymal stem cells.

Jia HY, Yu JH, Lei TC.

Abstract

BACKGROUND:

To investigate the in vitro multi-lineage differentiation of adipose-derived adult stem cells and their ability to differentiate into endothelial cells.

METHODS:

Adipose-derived adult stem cells were isolated for detection of the immune phenotype, cell doubling time, cycle, and induction of endothelial cell differentiation in vitro. The expression of endothelial cell-specific surface markers was measured immunocytochemically.

RESULTS:

Adipose-derived adult stem cells have multi-lineage differentiation potential and can differentiate into endothelial cells in vitro.

CONCLUSIONS:

Adipose-derived adult stem cells have the same differentiation ability with those derived from the bone marrow, as both can differentiate into endothelial cells. These findings have opened up the prospect of adipose-derived adult stem cells in angiogenesis therapy.