Regen Med. 2016 Sep 1. [Epub ahead of print]

Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease.

Misra S¹, Chopra K², Saikia UN³, Sinha VR⁴, Sehgal R⁵, Modi M⁶, Medhi B¹.

Abstract

AIM:

The present study investigated the efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in combination with galantamine hydrobromide-loaded solid lipid nanoparticles (GH-SLNs) in intracerebroventricular (ICV)-isoproterenol-induced rat model of Alzheimer's disease.

MATERIALS & METHODS:

BM-MSCs were harvested by dissecting femur and tibia of 8-10-week-old Wistar rats. 1 × 10⁶ cells were administered intravenously once in ICV-isoproterenol-induced rats followed by GH-SLNs (5 mg/kg) for 3 weeks.

RESULTS & CONCLUSION:

ICV-isoproterenol resulted in significant memory deficit. The results demonstrated rapid regain of memory in isoproterenol-induced amnesic rats, following single intravenous administration of BM-MSCs and oral administration of GH-SLNs for 21 days. The combination of BM-MSCs and GH-SLNs produced a more pronounced protective effect, therefore, could be explored for the management of Alzheimer's disease.