Placenta. 2016 Dec;48:99-103. doi: 10.1016/j.placenta.2016.10.015. Epub 2016 Oct 24.

Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing.

Tuca AC¹, Ertl J², Hingerl K², Pichlsberger M¹, Fuchs J¹, Wurzer P¹, Pfeiffer D², Bubalo V³, Parvizi D¹, Kamolz LP¹, Lang I⁴.

Abstract

Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.