Int J Mol Sci. 2017 Oct 20;18(10). pii: E2182. doi: 10.3390/ijms18102182.

Stem Cells as Potential Candidates for Psoriasis Cell-Replacement Therapy.

Owczarczyk-Saczonek A¹, Krajewska-Włodarczyk M², Kruszewska A³, Placek W⁴, Maksymowicz W⁵, Wojtkiewicz J^6,7,8.

Abstract

Recent years have seen considerable progress in explaining the mechanisms of the pathogenesis of psoriasis, with a significant role played in it by the hyper-reactivity of Th1 and Th17 cells, Treg function disorder, as well as complex relationships between immune cells, keratinocytes, and vascular endothelium. The effect of stem cells in the epidermis and stem cells on T cells has been identified and the dysfunction of various types of stem cells may be a prime cause of dysregulation of the inflammatory response in psoriasis. However, exploring these mechanisms in detail could provide a chance to develop new therapeutic strategies. In this paper, the authors reviewed data on the role played by stem cells in the pathogenesis of psoriasis and initial attempts at using them in treatment.