Curr Stem Cell Res Ther. 2018 Apr 26. doi: 10.2174/1381612824666180426120459. [Epub ahead of print]

Non Pregnant Human Uterus As Source Of Mesenchymal Stem Cells.

Eiro N¹, Fraile M¹, Schneider J², Vizoso F¹.

Abstract

Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfully in autologous or allogeneic transplantation, and all this in accordance with the applicable guidelines of good manufacturing practice. Thus, the identification and characterization of alternative sources of mesenchymal stem cells (MSCs) is of great importance. The human uterus emerges as an interesting source of MSCs. Both endometrial MSCs (eMSCs) and human uterine cervical stem cells (hUCESCs) easily to be obtained with minimal morbidity. Both eMSCs and hUCESCs show a high proliferation rate, which allows to harvest high amounts of them, both for research studies and potential therapeutic uses. It has been demonstrated that eMSCs have wide capability of differentiation into many cellular lineages, as well as potential therapeutic effects in several pathological processes. On the other hand, hUCESCs'secretome (conditioned medium) shows potent anti-inflammatory, anti-tumor, anti-bacterial and regenerative properties.