Muscle Nerve. 2018 Jul 20. doi: 10.1002/mus.26196. [Epub ahead of print]

Effects of mesenchymal stromal cells on type 1 diabetes mellitus rat muscles.

Sabadine MA¹, Russo TL², Luna GF¹, de Oliveira Leal AM¹.

Abstract

INTRODUCTION:

Type 1 Diabetes Mellitus (DM) causes marked skeletal muscle atrophy. Mesenchymal stromal cells (MSCs) are an attractive therapy to avoid diabetic complications due to their ability to modify the microenvironment at sites of tissue injury. The aim of this study was to evaluate the effects of MSC transplantation on muscle adaptation caused by diabetes.

METHODS:

DM was induced by Streptozotocin (STZ) and the diabetic animals received systemic MSC transplantation. The Von Frey test and footprint analysis assessed sensation and sensoriomotor performance, respectively. Tibialis anterior muscles were investigated by morphology, and molecular markers atrogin-1/MuRF-1, NF-κB/p38 MAPK, TWEAK/Fn-14, Myostatin, Myod and IGF-1 were also assessed.

RESULTS:

MSC transplantation improved sensation and walking performance and also decreased muscle fibrosis in DM rats by modulating atrogenes, but not preventing muscle atrophy.

DISCUSSION:

MSCs can reduce muscle and functional complications due to type 1 DM in rats. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.