J Tissue Eng. 2018 Jul 11;9:2041731418784098. doi: 10.1177/2041731418784098. eCollection 2018 Jan-Dec.

Osteoblast response to disordered nanotopography.

Allan C¹, Ker A¹, Smith CA¹, Tsimbouri PM¹, Borsoi J¹, O'Neill S¹, Gadegaard N¹, Dalby MJ¹, Dominic Meek RM¹.

Abstract

The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current uncemented orthopaedic implants can fail if the implant fails to bind to the surrounding bone and, typically, forms a soft tissue interface which reduces direct bone contact. Here, we look at the effect of a previously reported nanotopography that utilises nanodisorder to influence mesenchymal stromal cell (as may be found in the bone marrow) differentiation towards bone and to also exert this effect on mature osteoblasts (as may be found in the bone). As topography is a physical technique, it can be envisaged for use in a range of materials such as polymers and metals used in the manufacture of orthopaedic implants.