Adv Exp Med Biol. 2018 Jul 27. doi: 10.1007/5584_2018_251. [Epub ahead of print]

Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration.

Goodarzi P¹, Larijani B², Alavi-Moghadam S³, Tayanloo-Beik A³, Mohamadi-Jahani F¹, Ranjbaran N³, Payab M⁴, Falahzadeh K⁵, Mousavi M⁵, Arjmand B^6,7.

Abstract

Wound healing is a complex process with the considerable burden on healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to storage, and stability in the body. These advantages make them as a novel approach in regenerative medicine without the limitations of cellular therapy. In this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.