Hosp Pract (1995). 2018 Jul 27. doi: 10.1080/21548331.2018.1505181. [Epub ahead of print]

Intra-articular injections of fat-derived mesenchymal stem cells in knee osteoarthritis: are they recommended?

Rodriguez-Merchan EC¹.

Abstract

INTRODUCTION:

Knee osteoarthritis (OA) is one of the preeminent musculoskeletal illnesses in the adult population.

AIM:

To investigate the role of intra-articular injections of joint fat-derived mesenchymal stem cells (MSCs) in knee OA.

METHODS:

A Cochrane Library and PubMed (MEDLINE) search related to the role of intra-articular injections of joint fat-derived MSCs in knee OA was analysed.

RESULTS:

Experimental and clinical studies on intra-articular injections of joint fat-derived MSCs have provided satisfactory results (pain relief) in the short term. However, the results of a systematic review are controversial (more consistent trials are required for conclusive analysis).

CONCLUSIONS:

The insufficient information found on the role of intra-articular injections of fat derived MSCs in knee OA, leads me to conclude that the technique is not appropriate for the management of OA. Raising false expectations and hopes to patients with knee OA should be eluded.