Int J Biochem Cell Biol. 2018 Dec 14. pii: S1357-2725(18)30268-1. doi: 10.1016/j.biocel.2018.12.008. [Epub ahead of print]

Induced Pluripotent Stem Cells: A New Strategy to Model Human Cancer.

Bindhya S¹, Sidhanth C¹, Shabna A¹, Krishnapriya S¹, M G², Ganesan TS³.

Abstract

Induced pluripotent stem cells are derived from adult somatic cells by ectopic expression of stem cell factors OCT4, SOX2, MYC and KLF4. These cells have characteristic features similar to embryonic stem cells. Although there exists in vitro and in vivo models of cancer, recapitulating the earliest events in the pathogenesis remain challenging. More recently, induced pluripotent stem cells have been generated to model human disease and cancer. There are advantages in the cancer models derived from these cells as compared to existing conventional approaches. Induced pluripotent stem cells have been generated from cancer cell lines, primary tumours and from those with an inherited predisposition to develop cancer. In addition, these cells provide a valuable tool in understanding the pathogenesis of familial cancer in its earliest stages, and to identify additional genetic alterations that are required to develop cancer. Furthermore, these cells can serve as a resource in drug screening and developing new therapies.