Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2019 May 15;33(5):634-639. doi: 10.7507/1002-1892.201901051.

[Progress of mesenchymal stem cells derived exosomes in wound repair].

[Article in Chinese; Abstract available in Chinese from the publisher]

Wang J¹, Yi Y², Zhu Y¹.

Abstract

in English, Chinese

Objective:

To summarize the research progress of mesenchymal stem cells derived exosomes (MSCs-EXOs) in wound repair in recent years.

Methods:

The literature about the role of MSCs-EXOs in wound repair at home and abroad was extensively consulted. The mechanism of MSCs-EXOs in wound repair and its clinical application prospects were summarized and analyzed.

Results:

MSCs-EXOs can inhibit early inflammatory reaction, promote angiogenesis, proliferation, and migration of epithelial cells, regulate collagen synthesis, and inhibit scar proliferation in the later stage of wound healing. Compared with MSCs, MSCs-EXOs have many advantages, such as high stability, easy storage, non-tumorigenicity, no proliferation, easy quantitative use, and so on. It has broad clinical application prospects.

Conclusion:

MSCs-EXOs can promote wound repair and hopefully develop into a clinical product to promote the repair of acute or chronic wounds.