Methods Mol Biol. 2019;1994:1-14. doi: 10.1007/978-1-4939-9477-9_1.

Cell-Based Assays Using Differentiated Human Induced Pluripotent Cells.

Cader Z¹, Graf M², Burcin M², Mandenius CF³, Ross JA⁴.

Abstract

This chapter describes the requirements and preconditions for using human induced pluripotent cell lines in assay development within the pharmaceutical industry. The joint collaborative effort between academic and pharma partners within the StemBANCC consortium which enabled the implementation of iPSC-derived cellular models for drug discovery is highlighted. This large collaborative scientific network has successfully derived a significant number of well-characterized patient-specific iPSC lines and established disease-relevant cellular assays, both of which are requirements for enabling pharmaceutical companies to develop more efficacious and safer medicines.