Muscle Nerve. 2019 Jun 22. doi: 10.1002/mus.26614. [Epub ahead of print]

Beneficial role of adipose-derived mesenchymal stem cells from micro-fragmented fat in a murine model of Duchenne Muscular Dystrophy.

Bouglé A^1,2, Rocheteau P^1,3, Briand D¹, Hardy D¹, Verdonk F^1,4, Tremolada C⁵, Hivelin M⁶, Chretien F^1,7.

Abstract

INTRODUCTION:

No etiologic therapy is available for Duchenne muscular dystrophy (DMD), but mesenchymal stem cells were shown to be effective in pre-clinical models of DMD. The objective of this study is to investigate the effect of micro-fragmented fat extracted on a murine model of DMD.

METHOD:

Fat tissue was extracted from healthy human subjects and injected intra muscularly into DMD mice. Histological analysis, cytokines and force measurement were performed up to 4 weeks after injection.

RESULTS:

DMD mice injected with micro-fragmented fat exhibit an improved muscle phenotype (decreased necrosis and fibrosis), a decrease of inflammatory cytokines and increased strength.

DISCUSSION:

Administration of micro-fragmented fat in key muscles may improve muscular phenotype in DMD patients. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.