J Cell Mol Med. 2019 Sep 26. doi: 10.1111/jcmm.14562. [Epub ahead of print]

Role of cardiac progenitor cell-derived exosome-mediated microRNA-210 in cardiovascular disease.

Wang L¹, Jia Q¹, Xinnong C¹, Xie Y², Yang Y¹, Zhang A³, Liu R¹, Zhuo Y¹, Zhang J¹.

Abstract

Cardiac progenitor cells are considered to be one of the most promising stem cells for heart regeneration and repair. The cardiac protective effect of CPCs is mainly achieved by reducing tissue damage and/or promoting tissue repair through a paracrine mechanism. Exosome is a factor that plays a major role in the paracrine effect of CPCs. By delivering microRNAs to target cells and regulating their functions, exosomes have shown significant beneficial effects in slowing down cardiac injury and promoting cardiac repair. Among them, miRNA-210 is an important anoxic-related miRNA derived from CPCs exosomes, which has great cardiac protective effect of inhibiting myocardial cell apoptosis, promoting angiogenesis and improving cardiac function. In addition, circulating miR-210 may be a useful biomarker for the prediction or diagnosis of related cardiovascular diseases. In this review, we briefly reviewed the mechanism of miR-210 derived from CPCs exosomes in cardiac protection in recent years.