Int J Biol Macromol. 2019 Oct 14. pii: S0141-8130(19)35397-8. doi: 10.1016/j.ijbiomac.2019.10.029. [Epub ahead of print]

Fabrication of Chitosan/PVA/GO/CuO patch for potential wound healing application.

Venkataprasanna KS¹, Prakash J¹, Vignesh S², Bharath G³, Venkatesan M⁴, Banat F³, Sahabudeen S², Ramachandran S⁴, Devanand Venkatasubbu G⁵.

Abstract

Wound healing is a common issue in our day to day life. Our immune system repairs the damaged tissue by itself and its a time-consuming process. The GO/CuO nanocomposite (NC) was synthesized through the sol-gel method. XRD, FT-IR, Raman, and TEM analysis were used to analysis the physico-chemical properties of the sample. The GO/CuO patches were prepared using chitosan (Cs)/poly vinyl alcohol (PVA) due to its biocompatibility and biodegradable nature. The obtained patches showed better antimicrobial and wound healing property than recently reported materials. The GO/CuO NC plays a major part in angiogenesis process and in the synthesis, stabilization of extracellular matrix skin proteins. Thus, GO/CuO NC enhance the wound healing mechanism by increasing cell proliferation, antimicrobial property and rapid initiation of inflammatory. Moreover, the antimicrobial activity of CuO, GO, GO/CuO and GO/CuO patch were tested against bacteria causing wound infections. Cs/PVA patch and Cs/PVA/GO/CuO patch were analyzed for swelling, evaporation and degradation behavior. Increase in cell viability and migration of NIH3t3 cells by NC patch shows a potential way for wound healing applications.