Int J Mol Sci. 2019 May; 20(10): 2462.

Mesenchymal Stem Cells—Potential Applications in Kidney Diseases

Benjamin Bochon,^1,† Magdalena Kozubska,^2,† Grzegorz Surygała,^3,† Agnieszka Witkowska,⁴ Roman Kuźniewicz,⁵ Władysław Grzeszczak,⁵ and Grzegorz Wystrychowski^5,*

Abstract

Mesenchymal stem cells constitute a pool of cells present throughout the lifetime in numerous niches, characteristic of unlimited replication potential and the ability to differentiate into mature cells of mesodermal tissues in vitro. The therapeutic potential of these cells is, however, primarily associated with their capabilities of inhibiting inflammation and initiating tissue regeneration. Owing to these properties, mesenchymal stem cells (derived from the bone marrow, subcutaneous adipose tissue, and increasingly urine) are the subject of research in the settings of kidney diseases in which inflammation plays the key role. The most advanced studies, with the first clinical trials, apply to ischemic acute kidney injury, renal transplantation, lupus and diabetic nephropathies, in which beneficial clinical effects of cells themselves, as well as their culture medium, were observed. The study findings imply that mesenchymal stem cells act predominantly through secreted factors, including, above all, microRNAs contained within extracellular vesicles. Research over the coming years will focus on this secretome as a possible therapeutic agent void of the potential carcinogenicity of the cells.