World J Stem Cells. 2019 Mar 26; 11(3): 167–179.

Published online 2019 Mar 26. doi: 10.4252/wjsc.v11.i3.167

PMCID: PMC6441937

Long non-coding RNA: The functional regulator of mesenchymal stem cells

Zhong-Yu Xie, Peng Wang, Yan-Feng Wu, and Hui-Yong Shen

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Abstract

Mesenchymal stem cells (MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for diseases. Therefore, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA (LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently, multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.