Stem Cells Int. 2020 Mar 5;2020:4173578. doi: 10.1155/2020/4173578. eCollection 2020.

Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells.

Espagnolle N^1,2, Hebraud B³, Descamps JG^1,2, Gadelorge M^1,2, Joubert MV^4,5, Ferreira LDS^4,5, Roussel M³, Huynh A³, Sensébé L^1,2, Casteilla L¹, Attal M^3,5, Avet-Loiseau H^4,5, Deschaseaux F^1,2, Bourin P⁶, Corre J^4,5.

Abstract

Multiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM). As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission. We and others had demonstrated that BM-derived mesenchymal stromal cells (MSCs) are abnormal in MM and thus cannot be used for autologous treatment to repair bone damage. Adipose stromal cells (ASCs) represent an interesting alternative to MSCs for cellular therapy. Thus, in this study, we wondered whether they could be a good candidate in repairing MM bone lesions. For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. In contrast to MM MSCs, MM ASCs did not exhibit major abnormalities. However, the changes observed in MM ASCs and the supportive property of ASCs on MM cells question their putative and safety uses at an autologous or allogenic level.