Molecules. 2020 Mar 4;25(5). pii: E1150. doi: 10.3390/molecules25051150.

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms.

Cota-Coronado A^1,2, Durnall JC², Díaz NF³, Thompson LH², Díaz-Martínez NE¹.

Abstract

Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug discovery with clear advantages over the use of primary tissues. This is important considering the financial and social burden of neurological health care worldwide, directly impacting the life expectancy of many populations. Patient-derived iPSCs-neurons are invaluable tools for novel drug-screening and precision medicine approaches directly aimed at reducing the burden imposed by the increasing prevalence of neurological disorders in an aging population. 3-Dimensional self-assembled or so-called 'organoid' hiPSCs cultures offer key advantages over traditional 2D ones and may well be gamechangers in the drug-discovery quest for neurological disorders in the coming years.