J Hematol. 2020 Apr;9(1-2):9-12. doi: 10.14740/jh628. Epub 2020 Apr 23.

Factors Associated With Umbilical Cord Blood Collection Quality in Japan.

Suzuki S¹, Kimura T², Hara S³, Ishimaru F⁴, Takanashi M⁵.

Abstract

BACKGROUND:

Umbilical cord blood (UCB) has become an established alternative source of hematopoietic stem cells with marrow and postmobilization peripheral blood. The presence of a large amount of clots may lead to the deterioration of cord blood quality. To improve UCB quality as a source of hematopoietic stem cells in Japan, we examined factors associated with UCB collection methods from the viewpoint of eliminating the presence of clots.

METHODS:

In August 2019, we requested the directors of 74 certified facilities to provide information on UCB collection methods in Japan. A total of 46 (62.2%) of them responded with valid information on a total of 2,892 UCB collections. In this study, collected UCB without clots macroscopically was evaluated as a high-quality UCB.

RESULTS:

The 2,891 UCB collections described during the study period were divided to those with (n = 760, 26.3%) and without clots (high quality; n = 2,131, 73.7%). Multivariate analysis revealed single puncture as a factor determining high-quality UCB collection (adjusted odds ratio (ORs): 1.80, 95% confidence interval (CI): 1.3 - 5.4, P = 0.01).

CONCLUSIONS:

Single puncture is an independent effective factor determining high-quality manual UCB collection in Japan.