Int J Mol Sci . 2017 Nov 18;18(11):2449. doi: 10.3390/ijms18112449.

Can Youthful Mesenchymal Stem Cells From Wharton's Jelly Bring a Breath of Fresh Air for COPD?

Andrzej M Janczewski  ¹ , Joanna Wojtkiewicz  ^{2   3   4} , Ewa Malinowska  ⁵ , Anna Doboszyńska  ⁶

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality, projected to become the 3rd cause of disease mortality worldwide by 2020. COPD is characterized by persistent and not fully reversible airflow limitation that is usually progressive and is associated with an abnormal chronic inflammatory response of the lung to noxious agents including cigarette smoke. Currently available therapeutic strategies aim to ease COPD symptoms but cannot prevent its progress or regenerate physiological lung structure or function. The urgently needed new approaches for the treatment of COPD include stem cell therapies among which transplantation of mesenchymal stem cells derived from Wharton's jelly (WJ-MSCs) emerges as a promising therapeutic strategy because of the unique properties of these cells. The present review discusses the main biological properties of WJ-MSCs pertinent to their potential application for the treatment of COPD in the context of COPD pathomechanisms with emphasis on chronic immune inflammatory processes that play key roles in the development and progression of COPD.