Int J Dev Neurosci . 2019 Aug;76:80-85. doi: 10.1016/j.ijdevneu.2019.07.005. Epub 2019 Jul 11.

Application of Stem Cells and Chitosan in the Repair of Spinal Cord Injury

Xinyuan Hu  ^{1   2} , Xinru Zhou  ^{1   2} , Yang Li  ^{1   2} , Qian Jin  ^{1   2} , Wenjuan Tang  ^{1   2} , Qun Chen  ^{1   2} , Dilhumar Aili  ^{1   2} , Hui Qian  ^{1   2}

Abstract

Cytology and histology obstacles have been the main barriers to multiple tissues injury repair. In search of the most promising treatment strategies for spinal cord injury (SCI), stem cell-based transplantation coupled with various materials/technologies have been explored extensively to enhance SCI repair. Chitosan (CS) has demonstrated immense potential for widespread application in the form of scaffolds and micro-particles for SCI repair. The current review summarizes the evidences for stem cell-based transplantation and CS in SCI repair. Stem cells transplantation, which plays a key role in the repair of SCI, mainly results from its neural differentiation potential and neurotrophic effects. Application of CS enhances the survival of grafted stem cells, upregulates the expression level of neurotrophic factors and heightens the neural differentiation of stem cells as well as the functional recovery of spinal cord. Meanwhile, CS can also be exploited as growth factors/RNA carriers to control t he release of regenerating molecules which are beneficial to damage spinal cord repair.