Biochim Biophys Acta Mol Basis Dis . 2020 Apr 1;1866(4):165315. doi: 10.1016/j.bbadis.2018.10.033. Epub 2018 Nov 30.

Mesenchymal Stem Cells to Treat Type 1 Diabetes

John S Pixley  ¹

Abstract

What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. This effort exams the history or background of stem cell research in the laboratory and the clinic, types of stem cells, pluripotency or lack thereof based on a variety of pre-clinical investigations attempting endocrine pancreas recovery using stem cell transplantation. The focus is on the use of hematopoietic and mesenchymal stem cells. This review will also examine recent clinical experience following stem cell transplantation in patients with type 1 diabetes.