Biotechnol Appl Biochem . 2020 Jan 24. doi: 10.1002/bab.1891. Online ahead of print.

Recent advances in neurogenic and neuroprotective effects of curcumin through the induction of neural stem cells

Shadi Heidari  ¹ , Sina Mahdiani  ² , Maryam Hashemi  ³ , Fatemeh Kalalinia  ⁴

Abstract

Curcumin is extensively used in the prevention and treatment of various diseases. Recently, growing attention has been paid to the use of curcumin as a neurogenic and neuroprotective agent. This review study is aimed to collect and categorize the recent findings regarding the effects of curcumin on various neurological diseases through the induction of neural stem cell proliferation and differentiation. In addition, we have discussed the molecular mechanisms modulated by curcumin that contribute to this efficacy and have summarized the recent advancements in the novel delivery strategies used to improve the induction of neural stem cells by curcumin.