Adv Exp Med Biol . 2020;1237:29-36. doi: 10.1007/5584_2019_421.

Vascular Wall as Source of Stem Cells Able to Differentiate Into Endothelial Cells

Roberto Tamma  ¹ , Simona Ruggieri  ¹ , Tiziana Annese  ¹ , Domenico Ribatti  ²

Abstract

The traditional view of the vascular biology is changed by the discovery of vascular progenitor cells in bone marrow or peripheral blood Further complexity is due to the findings that the vessel walls harbor progenitor and stem cells, called vascular wall-resident vascular stem cells (VW-VSCs), able to differentiate to mature vascular wall cells. These immature stem/progenitor cell populations and multipotent mesenchymal lineage participate in postnatal neovascularization and vascular wall remodeling. Further studies are necessary to deepen the knowledge on characterization and biology of VW-VSCs, in particular of endothelial progenitor cells (EPCs) in order to improve their use in clinical settings for regenerative approaches.