SCIENCE-JOBS-DE

Metabolic signaling via mTOR kinase in tumors

In the research group for Metabolic Signaling, Faculty of Medicine
and Health Sciences, University of Oldenburg, Germany

a PhD student position is available as of February 1st 2015.
to study metabolic signaling via mTOR kinase in tumors.

Salary will be according to TV-L up to level E 13 (75%). The position is available for 3 years.
The start date can be negotiated.

We focus on the analysis of the mammalian target of rapamycin (mTOR) signaling network, and its role in metabolic processes by means of biochemistry, proteomics, cell biology, and computational methods. Experiments are primarily conducted in tissue culture, and extend to mouse and xenograft models, and the genetic model organism C. elegans.
        mTOR, the mammalian target of the anti-cancer drug rapamycin, is deregulated in a large number of tumors and is involved in aging related disorders such as metabolic and neurodegenerative diseases. mTOR kinase exists in two structurally and functionally distinct multiprotein complexes, named mTOR complex 1 (mTORC1) and mTORC2. mTORC1, in response to growth factors (insulin), nutrients (amino acids), and energy (ATP), controls growth related processes such as translation, ribosome biogenesis, and autophagy. mTORC2 is a central metabolic regulator as well, and controls lipid and glucose homeostasis.

The ideal candidate will hold a masters (M. Sc.) degree in biology/ life sciences or equivalent with a strong interest in metabolic signaling research. Training in cell biology, protein biochemistry, and/or bioinformatics and computational modeling will be of advantage. Training/experience in molecular biology and signaling research will be a plus. The work language is English, and English proficiency (written and spoken) is thus a must. German and/or Dutch knowledge will be a plus. High motivation and team player qualities are essential to work in our international environment.

We offer an attractive work environment with excellent lab facilities and education, supportive and enthusiastic colleagues, and a competitive salary.

The University of Oldenburg is dedicated to increasing the percentage of women in science. Therefore, equally qualified female candidates will be given preference. Applicants with disabilities will be preferentially considered in case of equal qualification.


Please submit your complete application as PDF via email or by postal mail
by January 20 2015 at the latest to:

Prof. Dr. Kathrin Thedieck
Lab for Metabolic Signaling
European Medical School (EMS)
Universities of Groningen, NL and Oldenburg, D

Faculty for Medicine and Health Sciences, Dept. for Neurosciences, Neurogenetics
Carl von Ossietzky University Oldenburg
Carl-von-Ossietzky Strasse 9-11, 26129 Oldenburg, Deutschland
Email: kathrin.thedieck@uni-oldenburg.de

Please note that we cannot cover application costs. Your application documents will only be returned if an adequately postpaid envelope is included.