Area of research
Small RNAs direct gene silencing through a mechanism called RNA interference (RNAi). Mobile small RNAs are exchanged between organisms and trigger cross-kingdom RNA silencing during host-microbe interactions. Understanding the molecular aspects that determine cross-kingdom RNAi is the aim of this PhD project. This is of enormous interest for the improvement of RNAi-based crop protection strategies. We are currently using the broad-host plant pathogen Botrytis cinerea as a model system. As a virulence strategy, B. cinerea produces mobile small RNAs during host plant infection that hijack the host RNAi pathway and silence important plant immunity genes [1,2]. We are further interested in to explore mobile small RNAs with capacity to silence host genes produced by other pathogens or plant-interacting microbes. To reach these aims we will employ methods that include genome analyses coupled with small RNA profiling, bioinformatics to predict novel mobile small RNAs and their target genes, and genetic as well as biochemical assays.
- Weiberg A, Wang M, Lin FM, Zhao H, Zhang Z, Kaloshian I, Huang HD, Jin H: Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science 2013, 342:118-123.
- Weiberg A, Wang M, Bellinger M, Jin H: Small RNAs: A New Paradigm in Plant-Microbe Interactions. Annu Rev Phytopathol 2014, 52:495-516.
Candidate prerequisite
- Master`s Degree/Diploma in Biology, Genetics, Botany, Microbiology, Immunology or related fields.
- Experience in molecular biology, genetics, small RNAs, microbiology, and/or plant biology will be considered as an advantage.
- Ability to work independently and as part of an international and multidisciplinary laboratory.
- A strong desire to do research with high self-motivation and enthusiasm.
- Excellent organization skills and personal initiative.
- Excellent English communication skills (written, spoken).
Online application
Please submit your application to Dr. Arne Weiberg (a.weiberg@lmu.de) including a letter of motivation that briefly outlines your interest in research connected to this position, your CV, your list of publications, and further academic records until 28th of February 2015.
Don't forget to mention Naturejobs when applying.
Job details
Employer:Ludwig-Maximilians-Universität (LMU) in Munich
Website:http://www.genetik.bio.lmu.de
Location:Großhadener Strasse 2-4, Munich-Martinsried, Bavaria, Germany
Expires:February 28, 2015
Job type:PhD Studentship
Salary:Unspecified
Qualifications:Postgraduate - Master's degree
Employment type:Temporary
Job hours:Part-time