SUMMARY:
Organismal development or environmental stimuli challenge the homeostatic protein balance of individual cells or the entire organism. Protein homeostasis is typically maintained by a concerted interplay between protein translation, protein folding or turnover of unfolded or damaged proteins.  The ubiquitin proteasome system (UPS) regulates selective degradation of cellular proteins supporting cellular protein homeostasis and thereby maintains the proteome during stress and ageing. Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin. An age-related impairment of the UPS causes enhanced protein aggregation and affects lifespan. The ultimate goal of the proposed research is to answer the fascinating question as to how inter-cellular communication regulates the UPS during multicellular development, stress and ageing.

JOB DESCRIPTION:
We are seeking a highly motivated PhD candidate to join our team investigating the fundamental role of protein homeostasis mediated by the ubiquitin system. We are using both genetic and biochemical approaches primarily in the C. elegans but also in mammalian systems to investigate proteolytic networks in ageing and disease.

QUALIFICATION:
Applicants should have a solid background in molecular biology and experience in cell biology, genetics or biochemistry. PhD candidates should have demonstrated outstanding performance through their undergraduate studies. Besides creativity, a strong ability for problem solving through analytical thinking combined with an enthusiasm for scientific research is highly desirable. Additionally, we expect good communication skills and the ability for teamwork. The successful applicant will join an enthusiastic and collaborative group where a multidisciplinary approach is pursued. The starting date would be July 2015.