Focus of the working group are studies on the development of organs in mammals, and here in particular patterning and differentiation processes in embryonic development of the heart and the kidney in mice. At the molecular level we are interested in this transcriptional regulatory cascades and signaling pathways that control the interaction and differentiation of mesenchymal and epithelial cells in the development of these organs.
Tbx18 and Tbx20 are two genes of the T-Boxgenfamilie, their important role in the development of various organ systems, especially the heart, we were able to show by genetic analysis in the mouse. The projects should be processed target genes and protein interaction partners of these two T-box transcription factors are identified and functionally characterized. The results should help to understand the important role of these proteins for the development of heart and ureter at the molecular level.
The experimental approach includes a very wide range of modern genetic techniques in mice (transgenic, knock-out mice), molecular biological, biochemical, cellular and embryological techniques.
The / Candidates / in must have team spirit, resilience and self-motivation have, and bring interested in working on development of biological questions in the mouse. Desirable are good knowledge of molecular biology, embryological, experimental animals and / or cell biology techniques. FELASA certificates are desirable.
The adjustment is made according to the guidelines of the TV-L.
Motivated and qualified candidates / applicants send your inquiries and / or applications to:


Prof. Dr. Andreas Kispert
Institute of Molecular Biology
OE5250
Hannover Medical School
Carl-Neuberg-Str. 1
D-30625 Hannover
Email: Kispert.Andreas @ MH Hannover.de