Subjects : Biology

Topic: Thesis: PhD thesis : Chromosome segregation in mitosis in human cancer cells

Contact: Prof. Holger Bastians

Reply to : holger.bastians@uni-goettingen.de

Institution : Center for Molecular Biosciences Goettingen ( GZMB ) and University Medical Center ( UMG Location: 37077 Göttingen , Grisebachstrasse 8

The Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center Goettingen (UMG) offers

PhD student positions

in Molecular Oncology and Cell Biology

The position is available in the lab of Prof. Holger Bastians, PhD., at the Institute of Molecular Oncology.

The Bastians lab studies the mechanisms of chromosome segregation during mitosis in human cancer cells. This is highly relevant, since ongoing chromosome missegregation leading to aneuploidy is a hallmark of human cancer and can contribute to tumorigenesis, tumor progression and the development of therapy resistance.
The planned PhD project aims to investigate the role of abnormal microtubule dynamics as a key defect in cancer cells leading to abnormal progression of mitosis. In this regard we are interested in investigating the cross-talk of microtubules with the cytoskeleton, which might be crucial for chromosome segregation and also for cell migration and tumor cell invasion.

The project is based on our most recent publications, which are available upon request:
Stolz et al., Nature Cell Biology 2010
Ertych et al., Nature Cell Biology 2014
Stolz et al., Cell Cycle 2015
Stolz et al, EMBO Reports 2015

We are using human tissue culture cells as model systems and state-of-the-art cell biological and molecular biology methods including live-cell-microscopy, deconvolution microscopy, FACS analyses etc.

Applicants should hold a master degree in biological sciences (molecular medicine, human biology and related areas are preferred) and should have a keen interest in cell biology and molecular oncology.

Please send your full application including a statement of previous research experience and the names and addresses for two references as a single pdf file to:
Prof. Dr. Holger Bastians, Email: holger.bastians@uni-goettingen.de

Methods:

We are using human tissue culture cells as model systems and state-of- the-art cell biological and molecular biology methods Including live cell microscopy , deconvolution microscopy , FACS analyzes , etc.

Start date : June 5, 2015

Estimated Time: 3-4 yeasr

Payment : according TL – V