PhD  and Diploma projects in protein design and evolution are available in the group of Prof. Kirill Alexandrov at the Institute for Molecular Bioscience (IMB) in Brisbane, Australia starting in 2011-2012. We believe that many key biological questions can only be answered by novel technologies. We therefore in the process of developing a protein engineering platform combine in vitro gene and proteins synthesis with single molecule spectroscopic analysis on microfluidic devices.  We apply this technology to construction of artificial enzymatic and signaling cascades. We expect the candidate to develop a range of novel protein-based sensors for cell biological, diagnostic and biotechnological applications.  Additional information about the project is available upon request.

The IMB was established 10 years ago to spearhead Australian interdisciplinary research in organismal, cellular, chemical and structural biology. It is located in the newly built complex on the campus of The University of Queensland in Brisbane together with 3 other research institutes and numerous research departments. IMB is exceptionally well equipped and funded and provide the vibrant research environment with more than 50 research groups.

We are seeking candidates with the background in molecular biology, biotechnology, bioengineering, chemistry, biochemistry, or structural biology and strong interest in interdisciplinary research. The application for a PhD program at the IMB is a competitive process and the candidates should be sufficiently qualified to obtain the University fellowship.

Starting date is flexible.

methods:
Recombinant protein expression in vitro and in vivo, fluorescent spectroscopy, microfluidics, X-ray crystallography, directed protein evolution

Start date: 1 May 2012

Estimated duration: 3.5 years

Payment: A $ 2000 / month

Subjects: Biology, Chemistry Pharmacy Physics
Topic: dissertation / thesis: New technologies for protein design and evolution
Contact: Professor Kirill Alexandrov
Reply to: k.alexandrov @ uq.edu.au
Institution: Institute for Molecular Bioscience, University of Queensland
Location: 4027 Brisbane, Australia, 306 Carmody rd