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PhD Student : Heidelberg, Germany

The German Cancer Research Center (DKFZ), the largest biomedical research institute in Germany operates a comprehensive program in the field of cancer research. Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

For the partner site of DKTK München the German Cancer Research Center is seeking a

PhD Student
(Ref-No. 256/2015)

Description:
We are developing and deploying genetic tools and models to study molecular and translational aspects of cancer development. In the past few years we have pioneered the development of PiggyBac transposon-based technologies for genetic screening in vivo. These unique tools allow us to discover cancer-driving molecular processes that are difficult to be identified with other approaches to cancer genome analysis. We use these systems to dissect the genetic basis of cancer development, metastatic spread and treatment resistance directly in vivo, in a high-throughput manner, on a genome-wide scale (e.g. Science 2010, 330:1104-7; Nat Genet. 2011,43:470-5, Nat Genet. 2015,47(1):47).

In different, hypothesis-driven approaches we are developing specific genetic and infectious models of cancer. We deploy these models to study defined biological questions or for preclinical research in order to develop novel diagnostic and therapeutic strategies (e.g. Cancer Cell 2013, 18, 23(2):406).
Another focus is the development of methods to facilitate the functional annotation of cancer genomes. To this end we develop CRISPR/Cas9-based approaches for somatic gene editing in the mouse and use them for targeted mutagenesis, genetic screening and chromosome engineering in the context of gastrointestinal or haematopoietic cancers (e.g. PNAS 2015, Oct27).

We are a young and enthusiastic team and offer intensive training and mentoring. We use a broad spectrum of techniques, such as in vivo transposon mutagenesis, Cre/loxP, Flp/frt, multi-omics, RNAi, retroviral expression systems, CRISPR/Cas9 genome editing, in vivo molecular imaging etc. The proximity to the clinical facilities allows insights into clinically relevant aspects of cancer. We also intend to facilitate research experience abroad at the Wellcome Trust Sanger Institute, Cambridge, UK. The successful candidate will be employed under the umbrella of the German Cancer Consortium (DKTK) at DKFZ as well as at the Technical University of Munich (TUM). The lab is based in the heart of Munich, at the Klinikum Rechts der Isar (from 2016 onward at the same campus in the newly built TUM Central Institute for Translational Cancer Research: TranslaTUM).

Your profile:
Diploma thesis or master's degree in biology, biochemistry, molecular medicine or related fields. Previous exposure to and experience with basic biochemical and molecular biology techniques is essential.

Please submit your application, including a letter of motivation, CV, certificates, recommendation letters in one pdf file.

The position is limited to 3 years.

The Translation Center is located in the premises of the Klinikum Rechts der Isar, Technische Universität München.

For further information please contact Prof. Dr. Roland Rad, roland.rad@tum.de.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Don't forget to mention Naturejobs when applying

Employer:German Cancer Research Center (DKFZ).

Website:http://www.dkfz.de/de/index.html

Location:Im Neuenheimer Feld 280, Heidelberg, Germany

Expires:January 25, 2016

Job type:PhD Studentship

Salary:Unspecified

Qualifications:Postgraduate - Master's degree

Employment type:Unspecified

Job hours:Unspecified