PhD position available

Structural and functional characterization of proteins involved in histone code reader epigenetic control mechanisms
A joint international 4-year studentship is proposed between the University Medical Center Freiburg (Germany) and Diamond Light Source (UK). The project characterises structural and functional aspects of specific methyl-lysine recognition by histone code reader proteins. Histones are subject to a plethora of post-translational modifications including lysine methylation. Placement, removal, and recognition of lysine methyl marks by typewriter eraser, and reader proteins contribute to the control of cell functions by regulating chromatin structure and gene transcription. In the course of the study the functions of selected reader proteins will be investigated using biochemical, molecular biology, and structural biology techniques.
        The project provides an outstanding opportunity for a PhD candidate to take advantage on the one hand of the excellent scientific environment of the University Medical Center Freiburg with state-of-the-art expertise in biochemical and molecular biology techniques, cell culture systems, and mouse models. On the other hand, Diamond Light Source, a world leading third generation synchrotron facility, provides a strong beam line portfolio and to active beamline development program combining a wealth of expertise in macromolecular crystallography, technique and software development, and access to other techniques relevant for structural studies available at Diamond, the Research Complex at Harwell, and on the Harwell Science and Innovation Campus.

Duration: 4 years
Degree awarded by University of Freiburg (Germany)

We seek a highly motivated candidate with a strong interest in molecular and structural biology. The successful candidate is expected to spend about half of the time first at the University Medical Center Freiburg and the other half at Diamond Light Source. Interested candidates should send their CV to the people listed below.

Prof. Roland Schuele, e-mail: @ roland.schuele uniklinik-freiburg.de
Dr. Holger Greschik, e-mail: @ holger.greschik uniklinik-freiburg.de
Dr. Ralf Flaig, e-mail: @ ralf.flaig diamond.ac.uk

http://www.uniklinik-freiburg.de/molgyn/live/index_en.html?weiterleitung=ja
http://www.diamond.ac.uk/Home/Beamlines/MX.html



Methods:
biochemistry
molecular biology
macromolecular crystallography

Start Date: 7 January 2013

Estimated duration: 4 years

Homepage: http://www.uniklinik-freiburg.de/molgyn/live/index_en.html?weiterleitung=ja

We seek a highly motivated candidate with a strong interest in molecular and structural biology. The successful candidate is expected to spend about half of the time first at the University Medical Center Freiburg and the otherhalf at Diamond Light Source.