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Postdoctoral Position in Cell Fate Reprogramming and Epigenetics : Leuven, Belgium

Description

We are looking for a talented and motivated postdoctoral scientist to join our new team.

 

Background:

A critical feature of somatic cells is that they usually do not switch from one cell type to another. Somatic cells can nevertheless be reprogrammed to alternative cell fates. One striking example of cell fate reprogramming is the conversion of somatic cells to induced pluripotent stem cells (iPS cells), which can be induced by the expression of just four transcription factors. iPS cells can not only be derived from patients, but they can also generate all different cell types of the body. Despite rapid advances, our understanding of how factor-induced pluripotency works is still limited, but is important for the generation of disease models, the design of cell replacement therapies, and for those interested in understanding cell fate control and epigenetic regulation in general.

 

The Project:

Factor-induced pluripotency requires a comprehensive change in gene transcription and a dramatic remodeling of chromatin. The efficiency of reprogramming of somatic cells to iPS cells is extremely low. This feature is thought to be the result of chromatin modifications that maintain cell identity and resist cell fate changes in our tissues. Several chromatin modifications that resist reprogramming have been identified, but the extent to which functional redundancy exists between different chromatin modifications for the maintenance of somatic cell identity remains unclear. Understanding the mechanisms that resist the reprogramming of somatic cells into iPS cells is expected to provide insights into the mechanisms that normally maintain and establish cell identity and go awry in diseases. The aim of this project is to:

 

1. Gain a better understanding of the kinetics and genomic context with which chromatin marks are reversed during different stages of factor-induced pluripotency starting from somatic cells.

2. Establish the functional redundancy between selected chromatin marks in maintaining somatic cell identity and in particular in opposing factor-induced pluripotency.

 

Working on this project will offer the candidate the opportunity to acquire experience in a wide range of techniques, including mouse transgenesis, reprogramming, pluripotent stem cell culture and derivation, CRISPR/Cas9 technology, viral transductions and state-of-the-art genomic tools including RNAseq and Reduced Representative Bisulfite Sequencing. There is also the very special opportunity to join the team in the exciting phase of starting the lab and therefore receive close mentorship and the possibility to contribute to the field rapidly.

 

We offer:

The project will be carried out in the lab of Vincent Pasque. The group has a solid international track record in studying the molecular basis of cell fate reprogramming. The scientific excellence of the team was recently recognized with a prestigious Odysseus grant, from which the successful postdoctoral candidate will be funded. The project will also involve collaborations with other excellent internationally recognized laboratories.

 

The University of Leuven is one of the top European Universities and provides an excellent research environment. Scientists have access to state-of-the-art technologies, core facilities (including genomics, single cell biology, proteomics, metabolomics, transgenesis, etc.), and technical support located in a new, purpose-built research building.

 

We offer a competitive salary and benefits (including excellent and inexpensive health care). The position is for 3 years, available immediately, with possibility of extension.

 

Located in the center of Europe (close to Brussels and with very good public transports), the position is ideal for international candidates.

 

Profile:

• We are looking for a very motivated individual, with a strong interest in cell fate reprogramming and epigenetic regulation.

• Candidates must have, or expected to obtain, a PhD in molecular or cellular biology, or a related field with a strong track record of research and publications.

• Prior experience in epigenetics, stem cell biology or developmental biology is important. Expertise in basic molecular biology techniques is necessary. Experience with genomics and bioinformatics is a plus.

• A good command of spoken and written English is essential and sufficient for communication within and outside the institute.

 

How to apply:

 

Successful candidates are encouraged to apply online using the following link:

https://webwsp.aps.kuleuven.be/esap/public/ui5_ui5/sap/zh_erc_esol_inl/index.html?sap-ui-language=EN&vacaturenummer=53670920&toepassing=LGH

 

The application file should contain a motivation letter, CV and publication list, including the names and contact details of 2 referees.

 

The University of Leuven is an equal opportunity employer, committed to excellence through diversity.

 

Application deadline: May 31, 2016.

 

Vincent Pasque

KU Leuven – University of Leuven

Stem Cell Institute

Department of Development and Regeneration

Herestraat 49

3000 Leuven, Belgium

Email: vincent.pasque@kuleuven.be

Tel: +32 1637 6283

http://www.kuleuven.be/samenwerking/scil/about_us/vincent_pasque

Don't forget to mention Naturejobs when applying.

 

Job details

Employer: KU Leuven

Website: http://www.kuleuven.be/samenw...

Location:Leuven, Belgium

Expires:May 31, 2016

Job type:Postdoctoral

Salary:Unspecified

Qualifications: Postgraduate - Doctorate/PhD

Employment type:Contract

Job hours: Full-time