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Postdoctoral Fellowships in Prostate Cancer : Cleveland, OH, United States
The Prostate Cancer Research Center of Excellence at Cleveland Clinic is directed by Nima Sharifi, M.D. and Eric Klein, M.D. and is composed of a multidisciplinary group of investigators with the stated purpose of defining the underlying clinical and biochemical behavior of the lethal form of prostate cancer and to identify new strategies to prevent symptoms and lethality from this disease. Postdoctoral fellowships are available for the following projects and Laboratories in the Center.
Nima Sharifi, M.D. – Identification of metabolic phenotypes of prostate cancer that confer resistance to androgen deprivation therapy, and the next-generation hormonal therapies, enzalutamide and abiraterone. See Chang, et al. Cell. 2013 154(5):1074-1084 and Li, et al. Nature. 2015 523(7560):347-51. Contact: sharifn@ccf.org
George R. Stark, Ph.D. and Robert H. Silverman, Ph.D. – Novel therapeutic approaches to prostate cancer, involving modification of poly(ADP) ribose by interferon-inducible proteins and consequent modulation of the DNA damage response. See Cheon, et al. EMBO J. 2013 32(20):2751-63 and Banerjee, et al. Oncotarget. 2015 6(42):44360-72. Contact: starkg@ccf.org; silverr@ccf.org
Angela Ting, Ph.D. and Eric Klein, M.D. – Our research focuses on understanding the functional impact of abnormal DNA methylation on prostate cancer aggressiveness. We employ next generation sequencing (NGS) technologies to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on prostate cancer biology. See Lee, et al. Cancer Research. 2013 73:1211-1218 and Bhasin, et al. Cell Reports. 13:2135-2146. Contact: tinga@ccf.org
Hannelore Heemers, Ph.D. – Defining how molecular heterogeneity in androgen receptor's transcriptional output translates into different modes of androgen receptor action and in novel opportunities for androgen deprivation therapy. See Heemers, et al. Cancer Res. 2011 71(5):1978-88 and Heemers HV. Int J Biol Sci. 2014 10(6):576-87. Contact: heemerh@ccf.org
These interdisciplinary projects have opportunities to interface with expert laboratory scientists, urologists, medical oncologists, pathologists and radiologists – all focused on prostate cancer.
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Job details
Employer:Cleveland Clinic
Location:Cleveland, OH, United States
Expires:August 07, 2016
Job type:Postdoctoral
Salary:Unspecified
Qualifications:Unspecified
Employment type:Unspecified
Job hours:Unspecified