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PhD Student: Heidelberg, Germany
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 2,700 employees, we operate an extensive scientific program in the field of cancer research.
The Division of Cancer Genome Research is seeking a
PhD Student
Characterization of molecular pathways determining prostate cancer progression
(Ref-No. 245/2016)
Description:
The group has strong expertise in gene expression analysis of cancers using microarray, qRT-PCR, and NGS technologies. We have established transcriptomic profiles of prostate cancer (PCa) and normal tissues and described molecular signatures for the classification of cancers and the prognosis of tumor progression. Based on these data, we are currently focusing on the in vitro analysis of signalling pathways and noncoding RNA in PCa progression.
The aim of this PhD project is to characterize cancer-associated signalling pathways on the basis of our previous work and to understand their functional roles in PCa formation and progression to highly aggressive disease. You will be using established cell culture systems and assays, overexpression or knockdown of selected genes (e.g. by the lentiviral CRISPR/Cas), high-throughput technologies including RNA-Seq and Chip-Seq, computational biology tools to analyze high throughput data, as well as other genomic and proteomic methods (e.g. qPCR, digPCR, Luminex). In vivo analyses using mouse models will be performed in cooperation with other groups. We also have long-lasting cooperations with experts in urology and urooncology which enables us to correlate the cellular data with clinical parameters.
Web: http://www.dkfz.de/en/krebsgenomforschung/index.php
Your profile:
- Master degree or equivalent in biology, biochemistry, biotechnology or related fields
- Expertise in RNA biology, gene regulation, and signal transduction pathways
- Hands-on experience in bioinformatic analyses
- Strong motivation to perform translational research
- Excellent command of written and oral English
We offer:
- Excellent working environment
- Access to state-of-the-art equipment
- Well-established collaborations
- Multiple opportunities for advanced training
- Flexible working hours
The position is limited to 3 years.
For further information please contact
Prof. Dr. Holger Sültmann, phone +49 6221 56-5934.
The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
To apply for a position please use our online application portal (www.dkfz.de/jobs).
We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.
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Employer:German Cancer Research Center (DKFZ).
Website:http://www.dkfz.de/de/index.html
Location:Heidelberg, Germany
Expires:November 20, 2016
Job type:PhD Studentship
Salary:Unspecified
Qualifications:Postgraduate - Master's degree
Employment type:Contract
Job hours:Unspecified