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4-6 postdoctoral research fellows in mitochondrial genetics: Stockholm/Solna, Sweden

Division
The Division of Molecular Metabolism (read more about it here: http://ki.se/en/mbb/research-division-of-molecular-metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mtDNA expression and other aspects of mitochondrial metabolism. Both patient material (tissues and cells) and genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in these studies. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments.

The Division of Molecular Metabolism offers an outstanding research environment and a close
interaction between basic science and clinical science and diagnostics at the Centre for Inherited
Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly
founded Max Planck Institute for Biology of Ageing – Karolinska Institutet Laboratory (MPI-KI
laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in
molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory (SciLifeLab).

We are currently looking for highly motivated postdoctoral researchers, to join the research groups of Nils-Göran Larsson (one-two positions), Anna Wredenberg (one-two positions) and Joanna Rorbach
(two positions).

Nils-Göran Larsson (MD, PhD)
In the research group of Nils-Göran Larsson, we use the house mouse and fruit flies as model organisms to investigate the regulation of the maintenance and expression of the mtDNA. A variety of biochemical methods, structural biology and bioenergetics are also used. We also study the role of somatic mutations in mtDNA in disease and ageing.

Anna Wredenberg (MD, PhD)
The Wredenberg group studies molecular interactions that affect mitochondrial metabolism, both in
health and disease. Our research aims at identifying the molecular consequences of metabolic
derangements, by understanding how mitochondria function within the metabolic system. For this, we
use a range of model systems, including patient-derived cell lines, and genetically modified fruit flies or mouse models. The successful candidate will study the metabolic consequences of mitochondrial
dysfunctions, using a combination of molecular biological approaches.

Joanna Rorbach (PhD)
The newly established group of Joanna Rorbach is affiliated to the MPI-KI laboratory. The objective of
our research is to better understand post-transcriptional regulatory networks controlling gene expression in mitochondria; as a means to identify the pathways and factors important to human mitochondrial diseases and improve our understanding of fundamental mechanisms of eukaryotic cell function. More specifically, we focus on i) RNA-protein interactions in mitochondria in response to different environmental signals, ii) mitochondrial ribosome biogenesis and iii) biochemical and structural characterization of mitochondrial translation. We employ highly multidisciplinary approaches to address these questions, including ribosome profiling, high-throughput gene targeting, proteomic and cryo-EM methods.

Please state in your motivation letter, which of the three groups you are most interested in joining.
Also include the name of the group leader (Larsson, Wredenberg or Rorbach) in the file name of
your motivation letter.

Entry requirements
Applications are invited from enthusiastic and motivated individuals with a PhD in a relevant field. The applicant preferably has experience in cellular metabolism with a strong background in mitochondrialand molecular biology. Experience in mouse or drosophila genetics, mammalian cell culture, biochemistry, bioenergetics, structural biology, and in cryo-EM is of advantage, depending on project. Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating the applicants.

A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no
more than seven years before the last date of employment as postdoc.

Application process
An employment application must contain the following documents in English:

• Curriculum vitae
• List of publications
• Personal motivation letter, explaining your research interests (max 1 page)
• Contact information of at least two references

The application is to be submitted on the MyNetwork recruitment system. Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone. For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.
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Employer:Karolinska Institutet (KI)

Website:http://ki.se/en/about/startpage

Location:Stockholm/Solna, Sweden

Expires:November 16, 2016

Job type:Postdoctoral

Salary:Unspecified

Qualifications:Postgraduate - Doctorate/PhD

Employment type:Contract

Job hours:Full-time