The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 2,300 employees, we operate an extensive scientific program in the field of cancer research.

The Division of Molecular Genome Analysis is seeking for March 2013 a

PhD Student

(Ref-No. 9/2013)

Description:

The Division of Molecular Genome Analysis at the DKFZ aims at understanding molecular mechanisms leading to the transformation of the tumor microenvironment and its role in cancer initiation and tumor progression. A further hallmark of tumorigenesis is a reprogramming of cellular metabolism, and several oncogenes contribute to this process. Using an approach combining perturbation experiments and time-resolved proteomics and transcriptomics we aim to elucidate the impact of breast-cancer relevant oncogens on metabolic transformation.

Aim of this PhD project is the identification of proteins that can potentially serve as drug targets to revert the transformed metabolism of cancer cells. The successful candidate will use different breast cancer cell lines as model systems and monitor the impact of nutritional stress (high glucose, high load of fatty acids, insulin) and of inflammatory cues (e.g. cytokines). Identified targeted genes will be validated by targeted proteomics (reverse phase protein arrays) and by cellular assays. Quantitative proteomic data generated throughout this project will feed into a systems biology modeling approach that integrates metabolic pathways and cellular signaling.

Your profile:

We are looking for a highly motivated candidate with a vivid interest in cellular signaling, metabolism and breast cancer biology. Applicants should hold an above-average Diploma/Master's degree in biochemistry, biology or related fields. Experiences in basic methods of cellular biology, protein chemistry and molecular biology are a prerequisite. Please send a complete application including cover letter, curriculum vitae, high school diploma, University diploma and list of courses, summary of the thesis and contact information for two references via the DKFZ online application system

The position is limited for 3 years.

For further information please contact

Dr. Ulrike Korf, phone 06221 42-4765.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de/jobs).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Michaela Schneider

m.schneider@dkfz.de

Deutsches Krebsforschungszentrum

Heidelberg

Dr. Ulrike Korf