SCIENCE-JOBS-DE

Research Fellow / Postdoc Position (Dresden)

At TU Dresden, the Junior Research Group of Dr. Jared Sterneckert,
"iPS Cells and Neurodegenerative Disease" of the Center for
Regenerative Therapies Dresden (CRTD) is looking for, subject to
granted funds, a

Research Fellow / Postdoc Position
(Subject to personal qualification, employees are remunerated according to salary group E 13 TV-L)

The position ideally starts March 1st 2017 and is initially limited until November 30th 2019 with an optional extension. The period of employment is governed by the Fixed Term Research Contracts Act
(Wissenschaftszeitvertragsgesetz - WissZeitVG). The position offers the chance to obtain further academic qualification (e.g. habilitation thesis).
Dr. Sterneckert's group uses patient specific induced pluripotent stem (iPS) cells to generate models of neurodegenerative diseases, including Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Using a combination of gene editing, proteomics, and small molecules, we aim at understanding the mechanism(s) of pathogenesis and identifying novel treatments.
Position and Requirements
This aim of this project is to use CRISPR-Cas9 to generate iPS cells
carrying reporters for alpha-synuclein-GFP and TAU-mCherry to model PD
pathogenesis. In close cooperation with the Lead Discovery Center GmbH
and the teams of Simon Alberti and Anthony Hyman (Max Planck Institute
for Molecular Cell Biology and Genetics), as well as Thomas Gasser (Hertie Institute for Clinical Brain Research), these models will be used for a high-throughput screening campaign to identify novel therapeutic compounds.
This project is highly collaborative, involving multiple, and prestigious labs, and is expected to be awarded funding by the BMBF.
We seek highly motivated, ambitious, and talented scientists to join our
enthusiastic and collaborative team in an outstanding scientific
environment. We expect the following: an outstanding university degree
and PhD in Biology, Biomedicine or similar. Significant experience with cell culture is required. Experience with iPS cell culture and/or CRISPR/Cas9 mediated gene editing are preferred. Experience with
molecular/biochemical methods, including Western blotting, plasmid
construction/preparation, and immunofluorescence are helpful. In addition, applicants are required to have the ability to work in an international team; inter- and multidisciplinary thinking; high motivation; an integrative and cooperative personality with excellent communication and social skills; fluency in English - written and oral.
Applications from women are particularly welcome. The same applies to
people with disabilities.
Research Environment
The Center for Regenerative Therapies Dresden (CRTD) is a
interdisciplinary institute at CMCB with a research centre and Cluster of Excellence, comprising 18 core research groups. Complementing these
core groups is the CRTD Members network, an interdisciplinary
organization of around 80 principal investigators located at other research institutes in Dresden including the Carl Gustav Carus Faculty of Medicine and the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG).
Our mission is to understand the biology of stem cells and physiological and pathological tissue and organ repair in order to develop new treatments for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, haematological diseases, such as leukemia, metabolic diseases, such as diabetes, and bone diseases. Our scientists are encouraged to think outside the box and to explore untapped areas of knowledge in the regenerative potential of the human body, and to apply this knowledge to prevent or reverse disease processes.
To achieve our aims, we strongly support interdisciplinary research, with eighteen core groups in a network of 87 principal investigators from diverse research institutes on the Dresden campus, with expertise in everything from the biology of cells and tissues to biomaterials to
nanoengineering. The CRTD has become a major driving force on campus
and is ready to meet the challenges of moving new interventional
strategies from bench to bedside.
Application Procedure
Your application must include: 1. Cover letter, indicating current and future research interests and career goals; 2. Description of research experience and accomplishments, including summary of previous research done during your PhD (max. 2 pages); 3. List of publications, if applicable; 4. CV, including copies of degree certificates and transcript of grades (i.e. the official list of coursework including your grades); 5. Two letters of recommendation or contact information for two references, including current supervisor. Please submit your application by 22.12.2016 (stamped arrival date of TU Dresden applies) preferably by e-mail as a single pdf document (using "surname_firstname.pdf") to daniela.mohrich@tu-dresden.de (Please note: We are currently not able to receive electronically signed and encrypted data.) or via central mail service to the following address: TU Dresden, CRTD, Frau Daniela Mohrich, Fetscherstr. 105, 01307 Dresden, Germany. Please submit copies only, a!
 s your application will not be returned to you. Expenses incurred in attending interviews cannot be reimbursed.
daniela.mohrich@tu-dresden.de
Center for  Regenerative Therapies Dresden (CRTD), Junior Research Group "iPS Cells and Neurodegenerative Disease"
Dresden

Ansprechpartner: Daniela Mohrich, daniela.mohrich@tu-dresden.de