We have recently shown that liver dysfunction in sepsis depends on the signaling activity of PI3Kgamma as KO mice are protected against excretory failure. However, PI3Kgamma plays a crucial role in the migration of phagocytes from the bloodstream to sites of infection, a hallmark of the host response. The aim of this project is to unravel the role of PI3Kgamma in liver as opposed to immune cells to develop strategies to prevent the sepsis induced liver dysfunction without a concomitant immune defect.

More projects details: www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/

We expect:

•       a Master’s degree (or equivalent) in Molecular Medicine or related areas. Candidates about to earn their degree are welcome to apply.

•       desirable methodological skills for signaling studies in mammalian cells, basic techniques for characterization of phagocytes, basic knowledge transgenic mouse technology

•       high motivation and interest to join one of the interdisciplinary research areas of JSMC

•       creativity and interest to shape your own thesis project

•       an integrative and cooperative personality with enthusiasm for actively participating in the lively JSMC Community

•       very good communication skills in English (instruction language at JSMC)

We offer:

•       a highly communicative atmosphere within a scientific network providing top-level research facilities

•       a doctoral researcher position (TV-L E13, 65%) funded for three years based on the regulations of the German Research Foundation as well as generous research funding

•       a comprehensive mentoring program with supervision by a team of advisors

•       a top-level PhD training program with courses in state-of-the-art research technologies and soft skills

•       Jena – the German City of Science 2008: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous Friedrich Schiller University

Friedrich Schiller University Jena is an equal opportunity employer.

The application procedure takes place exclusively online via the JSMC website:

www.jsmc.uni-jena.de

Please acquaint yourself with the open PhD projects and the application process described on this website.

Selected applicants will be invited to the JSMC Recruitment Meeting in Jena, Germany (at the end of June/beginning of July). Awarding decisions will be made shortly thereafter, allowing the projects to start immediately.

Application deadline: May 1st, 2013 (12pm, CET)

Keywords:

medical sciences, medicine, human infectious diseases, infection mice models, immunology, host‐pathogen interactions,  microbiology, microbiologist, biology, molecular biology, biomolecular, pathogenesis, sepsis, sepsis induced organ failure, Candida albicans, Jena School for Microbial Communication, JSMC, Friedrich Schiller University of Jena, University hospital jena, Germany, PhD student position, doctoral researcher position, doctorate, PhD studentship

Katja Präfcke

apply@jsmc.info

Jena School for Microbial Communication (JSMC)

Jena, Deutschland

Ansprechpartner: Dr. Carsten Thoms