The research group „Tumor-Stroma Interactions“ in the Center for Oncology and  Institute for Tumorbiology (group leader: Sonja Loges, M.D., Ph.D.) of the University Hospital-Eppendorf in Hamburg, Germany is seeking a motivated

Funding is limited to three years, but prolongation for another two years is expected. The project aims at mechanistic analysis of leukemia-bone marrow stroma interactions in preclinical mouse models and primary leukemia cells. You can expect an interesting and challenging atmosphere, excellent working conditions and a beautiful harbour city offering a high level of quality of life. The research group is a young dynamic group embedded into an internationally staffed institution with many international collaborators.

Your project:

• Dissection of leukemia-bone marrow stroma interactions with the goal to preclinically develop novel stroma-based targets and/or decrease resistance towards established therapies.

•Using state-of-the-art syngeneic and xenograft transplantation models you will use biased approaches with previously identified candidate regulators as well as unbiased methodology including deep sequencing.

•Complementation of analyses by co-cultures with different bone marrow stroma cells including mesenchymal stem cells, endothelial cells, osteoblasts and osteoclasts.

•Preclinical validation of newly identified targets and subsequent translation to clinical samples.

Your skills:

•You successfully completed your PhD in biology, biochemistry, molecular biology or similar studies resulting in first-author publications in peer-reviewed journals.

•You have experience in the described in vivo and in vitro techniques and are used to work independently.

•Knowledge in leukemia biology, tumor-stroma interactions and conducting pre-clinical leukemia models are an advantage.

•Your written and spoken English is fluent.

•Motivation, flexibility and team spirit are your characteristics.

Your contact for questions: Sonja Loges; M.D., Ph.D., e-mail: s.loges@uke.uni-hamburg.de, pager +49-15221-2817536

We chose our personnel according to qualification. Disabled persons are preferred, if they hold similar qualifications.

We are looking forward to receive your application including a motivation letter, CV and 3 supported references until May 27th, 2013 to the Universitätsklinikum Hamburg-Eppendorf, GB Personal, Recht & Organisation, UJW Recruitment, Kzf.: 2013-05/150, Martinistr. 52, 20246 Hamburg, Germany oder via E-Mail an: bewerbung@uke.de (max. 2 MB in one pdf-file).

Frau Schild

bewerbung@uke.de

Universitätsklinikum Hamburg-Eppendorf

Hamburg

Ansprechpartner: Frau Dr. Loges; s.loges@uke.de