The German Cancer Research Center, the largest biomedical research institute in Germany operates a comprehensive program in the field of cancer research. Together with university partners at seven renowned partner sites, we have established the German Consortium for Translational Cancer Research (DKTK).

For the partner site of DKTK Munich the German Cancer Research Center is seeking a

PhD Student

(Ref-No. 97/2013)

Description:

We are deploying genetic models to study molecular and translational aspects of cancer development. One focus in the past few years was the development of transposon-based insertional mutagenesis tools for forward genetic screening in mice. We utilize these systems to uncover molecular mechanisms underlying tumour development, metastatic spread and treatment resistance in vivo (e.g. Science 2010, 330:1104-7; Nature Genetics 2011,43:470-5, Cancer Cell 2013, 18, 23(2):406). We are also performing genetic screening in vitro, including drug resistance screens in cancer cells. In separate - reverse genetic - approaches we are developing specific genetic and infectious models of solid and haematopoietic cancers to perform in depth analysis of gene function and to address diagnostic/therapeutic questions.

We are a young, enthusiastic team and offer intensive training and mentoring. The successful candidate will have the opportunity to learn a wide spectrum of molecular biology, biochemical and cell biology techniques. She/he will be exposed to cutting edge methods to study the genetic basis of cancer (e.g. transposon mutagenesis and next-generation sequencing). She/he will also be able to gain insights into clinically relevant aspects of cancer development through proximity to the clinical facilities and through the interdisciplinary composition of our team and closely collaborating groups. We intend to facilitate research experience abroad and plan a stay at the Wellcome Trust Sanger Institute, Cambridge, UK, in Prof. Allan BradleyĀ´s laboratory.

Your profile:

Diploma thesis or Masters degree in biology, biochemistry or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques is essential.

The position is initially limited for 3 years.

For further information please contact

Prof. Roland Rad, phone 089 4140 4374, Roland.Rad@lrz.tum.de

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de/jobs).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Michaela Schneider

m.schneider@dkfz.de

Deutsches Krebsforschungszentrum

Heidelberg