PhD Positions in Systems Biology
of Gene Regulation

We invite PhD students with an interest in questions of gene regulation and a background in molecular genetics or biochemistry to join our team at the Gene Center Munich. Our lab studies regulatory processes in Drosophila development at a systems level, using a combination of molecular genetics, biochemical, genomic, and computational approaches. Current research is focused on understanding how cis-regulatory elements ëcomputeí expression to produce defined spatio-temporal patterns, the architecture and function of core promoters, and the regulatory role of chromatin. Our long-term goal is an integrated quantitative model of transcriptional regulation that realistically captures the underlying molecular mechanisms.

The Gene Center is an interdisciplinary institute of the Ludwig-Maximilians-Universit‰t M¸nchen (LMU) whose 15 research groups study gene regulation at every level, from molecular mechanism to biological system. The Center provides a dynamic, interactive, and internationally diverse scientific environment, located within a vibrant biomedical research campus in Munich-Groflhadern.

Your project
PhD projects are available in the following areas:
§ decoding the regulatory logic underlying pattern formation in Drosophila segmentation using biochemical and synthetic biological methods;
§ understanding the role of nucleosomes in developmental gene regulation using functional and evolutionary genomics;
§ dissecting the Drosophila core promoter using large-scale genomic and synthetic biological approaches.

All projects are fully funded by the DFG or BMBF. They involve advanced methods aimed at tracking regulatory events at high resolution and throughput, such as next generation sequencing (ChIP-, RNA-, MNase-, and DNase-Seq) and reporter assays to measure the activity of synthetic regulatory elements in transgenic embryos or through high-end robotics/microscopy. Projects also offer the opportunity for close interaction with computational biologists to support data analysis and modeling.

Your background
Master or Diploma in Biochemistry, Biology, Bioengineering or related field, with substantial experimental experience in molecular biology and biochemistry; experience with model organism genetics and/or bioinformatics is a plus. Our ideal candidate has excellent technical skills, an enthusiasm for using and developing new techniques, and a
strong interest in working within a multi-disciplinary team of scientists.

All positions are available from September 1, 2013. Salaries will be at 65 % E13 TV-L. The LMU is an equal opportunity employer. Please send a single pdf-file with your application (including cover letter, CV, degrees, references) by September 6, 2013 to: Prof. Dr. Ulrike Gaul, email: office-gaul@genzentrum.lmu.de, Genzentrum, Ludwig-Maximilians-Universit‰t M¸nchen, Feodor-Lynen-Strasse 25,
81377 M¸nchen, http://www.gaul-lab.genzentrum.lmu.de

Job details

Employer:Ludwig-Maximilians-Universität

Website:http://www.gaul-lab.genzentru...

Location:81377, Munich, Germany

Expires:September 06, 2013

Job type:PhD Studentship

Salary:Unspecified

Qualifications:Unspecified

Employment type:Unspecified

Job hours:Unspecified