Work environment: We are an international laboratory for translational matrix biology with more than 20 researchers. We are closely linked to other core research facilities in Erlangen (Dep. of Rheumatology and Immunology, Dep. of Animal Physiology, and Interdisciplinary Center for Clinical Research). We have national and international cooperation partners in academics and industry. Our major gaols are to identify novel anti-fibrotic targets, elucidate the underlying pathogenic pathways and come up with candidate therapies for clinical use.

Topic: The PhD student’s project will focus on morphogen pathways in fibrosis of different organ systems (e.g., dermal and lung fibrosis). In our previous work, we have established morphogen pathways as key players in fibrotic disease, which includes profibrotic Wnt-, Notch- and Hedgehog-signaling. Findings from other fields suggest that these morphogen pathways could closely interact with each other. Based on our previous work, the PhD student will study the interactions of the morphogen pathways (Wnt – Notch and Wnt – Hedgehog, in particular) in the context of fibrosis. With a better knowledge of the morphogen network, the PhD student’s project can develop novel anti-fibrotic treatment approaches in preclinical models of fibrotic disease.

Requirements and application: We invite applications by students holding a master's or comparable degree in biological or biomedical sciences (biology, molecular biology, immunology, biochemistry) or equivalent degrees. We appreciate applications from highly motivated students with basic knowledge in the above-mentioned techniques. Previous work with in vivo models is desirable but not essential. Organizational and communication skills as well as the ability to work independently but also in a team are very welcomed. Good English skills are necessary to work within our laboratory. Funding for a 3-year employment is available.

methods:
Methods: We offer a broad spectrum of molecular techniques. The student will work with immunohistochemistry, immunofluorescence, qPCR, ELISA, WB, nucleofection, siRNA, reporter assay, ChIP assay among other methods. The student's project will Comprise various in vitro (cell culture) and in vivo systems (genetic and non-genetic mouse models).

Start date: 27 September 2013

Estimated Duration: 3 years

Payment: standard

Subjects: Biology, Chemistry, Pharmacy Veterinary Medicine
Topic: thesis / dissertation: Stem cell pathways in fibrotic diseases
Contact: PD Jörg D
Reply to: joerg.distler @ uk-erlangen.de
Institution: Department of Internal Medicine 3, University of Erlangen
Location: 91054 Erlangen, Ulmenweg 18
 

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