The Molecular Signaling and Cell Death Unit, headed by Prof. Dr. Peter Vandenabeele at the Inflammation Research Center at the VIB and Ghent University, has currently a job opening for a PhD student to investigate the interaction of cells undergoing apoptosis, immunogenic apoptosis and regulated necrosis with the innate and adaptive immune system. This knowledge will lead to the development of new experimental treatment strategies for cancer and autoimmune diseases.
The research unit of Prof. Dr. Peter Vandenabeele consists of more than 30 enthusiastic people working in the field of cell death and inflammation. You will be working in a subgroup, led by a senior postdoctoral scientist, Dr. Dmitri Krysko. The work will involve making use of cutting edge methods, including recombinant DNA technology, cell culture, analysis of gene and protein expression, anti-tumor vaccination, use of transgenic and knockout mice, flow cytometry, in vitro phagocytosis assay, and chemotaxis assays.
Selected references to previous work:
- A Kaczmarek, P Vandenabeele, DV Krysko Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013 38(2):209-23. (ISI IF 19.8).
- DV Krysko, AD Garg, A Kaczmarek, O Krysko P Agostinis, P Vandenabeele Immunogenic cell death and DAMPs in cancer therapy. Nature Reviews Cancer, 2012 15 12(12):860-75. (ISI-IF 35).
- G Ayna, DV Krysko, A Kaczmarek, G Petrovski, P Vandenabeele, L Fésüs ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages PLoS ONE. 2012 7(6): e40069. doi:10.1371/journal.pone.0040069 (ISI-IF 3.7).
- AD Garg, DV Krysko, T Verfaillie, A Kaczmarek, GB Ferreira, T Marysael, N Rubio, M Firczuk, C Mathieu, AJ Roebroek, W Annaert. J Golab, P de Witte, P Vandenabeele, P Agostinis A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 2012 31(5): 1062-1079. (ISI-IF 9.8).
- DV Krysko, A Kaczmarek, O Krysko, L Heyndrickx, J Woznicki, P Bogaert, A Cauwels, N Takahashi, S Magez, C Bachert, P Vandenabeele TLR-2 and -9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation. Cell Death and Differentiation 2011; 18(8):1316-25. (ISI-IF 8.85).
Starting date:
Any date after January 1st 2014
Period
2 years contract with 2 years extension upon positive evaluation
Profile
The applicant should have:
- a diploma of medical doctor or a master degree in immunology, inflammation, cellular biology, biochemistry or in related fields,
- excellent laboratory skills and communication skills in English,
- enthusiasm in research and
- ability to work both independently and in a team environment.
Experience in research using mouse models, imaging techniques and/or cell-cell interactions will be a plus.
How to apply?
Your application file should contain a motivation letter, CV and publication list (if applicable), a summary of your previous research experience, your marks and degrees during your Master studies and a reference letter of the promoter of your master thesis. The file should be submitted to Dr. Dmitri Krysko (mailto:Dmitri.Krysko@irc.vib-UGent.be).
For more information, please contact Dr. Dmitri Krysko by email….
Job details
Employer:Inflammation Research Center, a VIB-UGent department
Website:http://www.vib.be
Location:Gent, Belgium
Posted:3 days ago
Expires:December 13, 2013
Job type:PhD Studentship
Salary:Unspecified
Qualifications:Postgraduate - Master's degree
Employment type:Contract
Job hours:Full-time
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