The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 2,600 employees, we operate an extensive scientific program in the field of cancer research.

The Division of Medical Physics in Radiation Oncology is seeking a

PhD Student in Biology
(Ref-No. 209/2013)

Description:
The Heidelberg Ion Beam Therapy Centre (HIT) is treating patients since 2009 and aims to elucidate the clinical effectiveness of ion beams for the treatment of cancer. This new irradiation modality may be used separately or in combination with x-rays. Ion beams offer distinct physical and biological properties that enable the application of high local doses to the tumor while sparing the surrounding normal tissue. MoreÂŹover, the increased biological effectiveness of carbon ions relative to protons and photons has been shown to improve treatment results for certain tumor entities. Ongoing clinical trials are accompanied by a research program within the frame work of a Clinical Research Group (funded by DFG), which shall develop and integrate new technologies in beam delivery and treatment planning as well as to clarify underlying biological mechanisms. (For further details see also www.klinikum.uni-heidelberg.de/index.php?id=124292&L=1).

Within the sub-project: "Preclinical studies of the effect of heavy ions on normal tissues and hypoxic tumors", we offer a position for a PhD-Student in Biology.

Your profile:
The PhD-candidate should have a background in tumor biology and should have a strong interest in performing animal studies to determine the relative biological effectiveness (RBE) of heavy ions in experimental tumors. Ultimate goal is to measÂŹure complete dose-response curves and to determine the relative biological effectiveÂŹness of Carbon and Oxygen ions in tumors under different oxygenation conditions. Experiments include volumetric measurements, assessment of structural and funcÂŹtional parameters using non-invasive radiological techniques (CT, Ultrasound, MRI etc.), immunohistochemistry as well as gene and protein expression profiling.

We are looking for a highly motivated student able to work both, independently as well as in a team. Diploma or Masters in Biology, Biochemistry or related areas is required. Experience in animal experimentation as well as in histology and molecular biology is required.

Experience in tissue processing immunohistochemistry, and microscopy, is of advantage. Applications should include cover letter, CV, copies of high school exam (e.g. Abitur, Baccalaureat) and university exams and give details of 2 referees.

The position is limited for 3 years.

The candidate will be employed by the University Clinic Heidelberg.

For further information please contact
Prof. Dr. Christian Karger, phone 06221 56-38965.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de/jobs).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.


Michaela Schneider
m.schneider@dkfz.de
Deutsches Krebsforschungszentrum
Heidelberg

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