SCIENCE-JOBS-DE

PhD studentship (m/f) (68135 Mannheim)

Under the roof of the University Medical Center Mannheim the Mannheim Medical Faculty of Heidelberg University and the Mannheim University Hospital combine their efforts to provide high-level health care.
The Mannheim University Hospital is operating as a maximum service general hospital with a broad spectrum of diagnostic and therapeutic resources. More than 4500 employees are conducting an annual medical inpatient treatment for more than 70000 patients and numerous outpatient visits. The Mannheim Medical Faculty is part of the 627-year-old Heidelberg University. Scientific activities, including basic and clinical research, are reflected by numerous scientific publications, as well as conferences and seminars organized by its members

At the Medical Research Center (Director of the Medical Research Center: Prof. Dr. N. Gretz) of the Medical Faculty Mannheim of Heidelberg University a NIH (National Institute of Health, USA) funded position (PI Prof. Dr. Sigrid Hoffmann) is open for a


PhD studentship (m/f)

The current funding is for the extended for 2 years, although the potential exists to continue the position for longer, if the project is successful.

The position requires

a highly motivated, enthusiastic, energetic candidate to study molecular mechanisms of Polycystic Kidney Disease (PKD) in rats. PKD is one of the most common lethal genetic diseases. The PhD student will join a discovery-oriented project aimed to explore the function of a new largely unknown PKD gene Anks6 and its putative interaction partner Anks3, the mechanisms of their interaction and the pathways leading to PKD (e.g. Am J Pathol. 2010,177:3000-9; BMC Structural Biology 2014, 14:17). For this, Anks3 function and interaction with Anks6 is studied in vitro. In vitro findings will be further explored in rat lines with precise genome modifications in the Anks3 gene using cutting-edge genome editing methods and tools (e.g. CRISPR-Cas9/ZFN). The impact of Anks3 mutations on disease development will be studied by using a combination of standard molecular, biochemical, histomorphometrical, immunohistological and animal experimental methods. The project has the potential to expla!
 in a new player in the complex pathway to PKD. The PhD candidate will be part of a collaborative network between us and groups at UCLA, Los Angeles, USA and INSERM, Paris, France.

We offer, alongside the possibility to work on a cutting-edge project and outstanding research training employing a broad range of state-of-the-art techniques, a stimulating, diverse and international research environment at the University Heidelberg.

Applicants should have the following skills

The successful candidate should hold a Masterā€™s degree or equivalent in life sciences with solid background in molecular and cell biology. Technical skills in molecular cloning, standard DNA, RNA techniques and transfection technology are desirable. The candidate should be dedicated to the project, highly motivated, eager to learn new techniques, self-driving and able to work both independently and in close collaboration with the other team members.

Payment is according to the terms of the collective agreement of the government services of the German federal States (TV-L)
We support equal opportunities for women. Therefore, we look forward to applications by women with special interest. Handicapped applicants with equal skills will be employed preferentially.

Application deadline: 31.08.2014    Index number: 813/113

Did we arouse your interest? Then we look forward to your complete online application (CV, motivation letter, and contacts for at least 2 referees in a single file) under the following Link: www.bewerbung.umm.de

Personalabteilung
elke.heidrich@umm.de
UniversitƤtsmedizin Mannheim
68135 Mannheim