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Postdoc : Berlin, Germany

The German Cancer Research Center (DKFZ), the largest biomedical research institute in Germany, operates a comprehensive program in the field of cancer research. Together with university partners at seven renowned partner sites, we have established the German Consortium for Translational Cancer Research (DKTK).

For the partner site of DKTK Berlin the German Cancer Research Center is seeking a

Postdoc (m/f)
(Ref.-No. 131/2014)

Description:
We are interested in genetic programs and mutations, which impact on tumor development and sensitivity to anticancer therapies, in particular cellular senescence, apoptosis and autophagy. Utilizing transgenic mouse models, we generate primary lymphomas with defined genetic lesions (by intercrossing cancer-prone transgenics to knockout mice, and by retroviral gene transfer into established lymphoma cells or hematopoietic stem cells). These tumors are transplantable and undergo anticancer treatment at their natural sites. Using this tractable system, which recapitulates typical features of human Non-Hodgkin's lymphomas, we study genetic, biochemical and metabolic effects of oncogenic action and drug responses in vivo. Moreover, we are particularly interested in cancer stemness and plasticity / transdifferentiation. Using murine and human model platforms, we seek to identify cancer vulnerabilities for conceptually novel therapeutic strategies. Objective of the postdoc project is the generation (in collaboration) and in vitro / in vivo application of subgenome-wide RNA interference libraries (mouse and human) directed against certain functionalities in cancer cells. Our goal is the identification of synthetic lethal pathways or novel targets that exert their oncogenic properties under specific cancer-related circumstances. For information in greater detail please see, for example, Schmitt-CA et al., Nature Med. (2000), Schmitt-CA et al., Cancer Cell (2002), Schmitt-CA et al., Cell (2002), Braig-M et al., Nature (2005), Reimann-M et al., Cancer Cell (2010), Jing-H et al., Genes Dev. (2011), and Dörr-JR et al., Nature (2013).

Your profile:
Join our highly motivated team if you are interested in RNAi / omics-based approaches and novel strategies to dissect treatment- and outcome-relevant signaling modules in cellular senescence. You hold a Ph.D. or equivalent, and you are familiar with all basic techniques in molecular biology, biochemistry and histology (i.e. cloning, analyses of proteins and DNA / RNA, cell culture, and immunohistochemistry). Expertise in any of the following is preferred: genome-wide screens, RNA interference, retroviral / lentiviral vector design, inducible gene expression systems, proteomics / metabolomics, cellular bioenergetics, molecular, cellular or organismic imaging, work with immunocompromised mice, generation of transgenics / knockout mice, or analysis of large data sets and mathematical modeling approaches. Lab communication is in English. Please send your CV including a list of publications and two references / letters of recommendation.

The position is limited until December 31, 2015. The position can in principle be part-time.

The Translation Center is located in the premises of the Molecular Cancer Research Center, Charité – University Medicine Berlin, Campus Virchow Klinikum.

For further information please contact Prof. Dr. Clemens Schmitt, phone 030 450-559073.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (http://www.dkfz.de).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personal- und Sozialwesen, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

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Employer:German Cancer Research Center (DKFZ)

Website:http://www.dkfz.de

Location:Berlin, Germany

Expires:August 03, 2015

Job type:Postdoctoral

Salary:Unspecified

Qualifications:Unspecified

Employment type:Unspecified

Job hours:Unspecified